Table 7. Number of transcription factors (or polymerases) that maternally or paternally regulate GENCODE genes or novel TARs that are maternally or paternally expressed.
| Single TF | Maternal expression | Paternal expression |
|---|---|---|
| We see the maternal regulation is coordinated with maternal expression and similarly for paternal regulation with paternal expression. We also tabulate the breakdown of counts for two network motifs, multiple-input motifs (MIMs) and single-input motifs (SIMs), also see Figure 6. An MIM is where two TFs regulate the same target gene or novel TAR and an SIM is where one TF regulates two different targets. We again observe coordinated regulation in these network motifs. For SIMs, we also observe 1910 cases of the form MP → MP (opposite by coordinated regulation and expression) and 222 cases of MP → PM (mixed regulation and expression). | ||
| Maternal regulation | 81 | 22 |
| Paternal regulation | 31 | 64 |
| Multiple TFs (MIM) | Maternal expression | Paternal expression |
| Both maternal regulation | 40 | 0 |
| Both paternal regulation | 4 | 36 |
| Mixed regulation | 3 | 2 |
| Single TF (SIM) | Both maternal expression | Both paternal expression |
| Both maternal regulation | 2840 | 224 |
| Both paternal regulation | 254 | 1232 |