Table 1.
Phenotype of cells isolated from livers of naive (C3H and B10) animals, and syngeneic (C3H → C3H) and allogeneic (B10 → C3H) transplanted livers
| Naive (n=3) |
Liver cell yield (×l06) |
B cells (%) |
T cells (%) |
CD4+ (%) |
CD8+ (%) |
CD4:CD8 ratio |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B10 0.7±0.3 |
C3H 0.5±0.4 |
B10 31±4 |
C3H 38±5.1 |
B10 48±6.2 |
C3H 43±3.9 |
B10 41±5.4 |
C3H 29±4.3 |
B10 27±3.5 |
C3H 14±3.1 |
B10 2.07 |
C3H 2.01 |
|
| Time postTxa | syn | allo | syn | allo | syn | allo | syn | allo | syn | allo | syn | allo |
|
|
||||||||||||
| day 2 | 1.4±0.6 | 2.5±1.6 | 26±4.2 | 18±9 | 43±7.5 | 47±8.1 | 37±0.5 | 27±8.8 | 11±1.4 | 20 ±14 | 1.35 | 3.36 |
| 1 wk | 2.8±2.1 | 10±3.6 | 39±5.1 | 13±5 | 41 ±14 | 56±27 | 31±5.7 | 20±9.1 | 13±2.5 | 31±5.7 | 2.38 | 0.67 |
| 4 wk | 0.5±0.3 | 9.8±3.1 | 18±8.5 | 20±7 | 40±3 | 73 ±18 | 33±7.1 | 19±2.5 | 13±2.5 | 53±21 | 2.54 | 0.36 |
| 12 wk | NDb | 3.8±0.9 | ND | 28±9.5 | ND | 61±12 | ND | 18±3.5 | ND | 34±14 | ND | 0.53 |
a
n=4 at each time point after transplantation.
b
ND, not done.