Table 5.
Number (%) of respondents recording specific side effects after baseline influenza vaccination
| Side effects | H1N1p only | Seasonal only | H1N1p and seasonal | H1N1p/seasonal and other | Total | P valueb | H1N1p total | Not H1N1p total | P valuec |
|---|---|---|---|---|---|---|---|---|---|
| N (NMISSING) | 534 (160) | 106 (29) | 149 (75) | 35 (15) | 824 (279) | 714 (246) | 110 (33) | ||
| Flu-like symptomsa | 128 (24.0%) | 18 (17.0%) | 38 (25.5%) | 11 (31.4%) | 195 (23.7%) | 0.233 | 175 (24.5%) | 20 (18.2%) | 0.184 |
| Absenteeism due to flu-like symptoms | 9 (1.7%) | 2 (1.9%) | 5 (3.4%) | 1 (2.9%) | 17 (2.1%) | 0.486 | 15 (2.1%) | 2 (1.8%) | 1.000 |
| Time off due to flu-like symptoms | |||||||||
| None | 525 (98.3%) | 104 (98.1%) | 144 (96.6%) | 34 (97.1%) | 807 (97.9%) | 699 (97.9%) | 108 (98.2%) | ||
| One day | 1 (0.2%) | 1 (0.9%) | 0 (0.0%) | 0 (0.0%) | 2 (0.2%) | 1 (0.1%) | 1 (0.9%) | ||
| 1–3 days | 5 (0.9%) | 1 (0.9%) | 1 (0.7%) | 1 (2.9%) | 8 (1.0%) | 0.198 | 7 (1.0%) | 1 (0.9%) | 0.339 |
| >3 days | (0.6%) | (0.0%) | 4 (2.7%) | 0 (0.0%) | 7 (0.8%) | 7 (1.0%) | 0 (0.0%) | ||
| N (NMISSING) | 688 (6) | 131 (4) | 220 (4) | 49 (1) | 1088 (15) | 949 (11) | 139 (4) | ||
| Muscular side effects | 131 (19.0%) | 11 (8.4%) | 48 (21.8%) | 11 (22.4%) | 201 (18.5%) | 0.006 | 190 (20.0%) | 11 (7.9%) | <0.001 |
| Narcolepsy/seizure | 42 (6.1%) | 3 (2.3%) | 15 (6.8%) | 3 (6.1%) | 63 (5.8%) | 0.273 | 60 (6.3%) | 3 (2.2%) | 0.051 |
Notes: Patients who had responded that they were ‘generally’ affected were asked to give more details of these side effects. Options were flu-like symptom; fever; tingling; disturbed sleep; loss of appetite; muscle weakness; muscle pain; shaking; dizziness; sleep problems; liver problems; weight gain; general lethargy/tiredness; feelings of extreme cold; sweating; allergic reaction; other. All options which applied could be ticked. Number (%) of respondents ticking flu-like symptoms are displayed with number (%) recording that they took any time off due to flu-like symptoms;
P value from Fisher exact test on the difference between the four vaccine groups;
P value from Fisher exact test on the difference between respondents receiving H1N1p vaccine and those receiving vaccines other than H1N1p (seasonal/seasonal + other).