Table 2. Odds ratios (ORs)a and 95% confidence intervals (CIs) for the previously reported rs4415084 and rs10941679 SNPs.
| SNP | High-risk allele frequency (%) | Heterozygous OR (95% CI) |
Homozygous OR (95% CI) |
Per-allele OR (95% CI) |
P for trend | |
|---|---|---|---|---|---|---|
| Cases (N) | Controls (N) | |||||
| rs4415084_T | ||||||
| All cases | 63.4 (868) | 60.5 (1,075) | 1.10 (0.84, 1.44) | 1.26 (0.96, 1.65) | 1.13 (0.99, 1.28) | 0.06 |
| ER + cases | 65.7 (262) | 1.16 (0.76, 1.77) | 1.51 (0.99, 2.31) | 1.25 (1.02, 1.52) | 0.03 | |
| ER− cases | 60.3 (172) | 0.81 (0.51, 1.29) | 0.87 (0.55, 1.40) | 0.96 (0.76, 1.21) | 0.96 | |
| rs10941679_G | ||||||
| All cases | 18.7 (846) | 16.7 (1,056) | 1.27 (1.04, 1.56) | 0.98 (0.61, 1.58) | 1.14 (0.97, 1.35) | 0.11 |
| ER + cases | 20.0 (258) | 1.35 (1.00, 1.83) | 1.12 (0.56, 2.22) | 1.21 (0.95, 1.53) | 0.10 | |
| ER− cases | 17.2 (170) | 1.17 (0.81, 1.69) | 1.04 (0.45, 2.40) | 1.10 (0.82, 1.47) | 0.84 | |
a
Adjusted for age, geographical region of residence, place of birth, and percent European admixture