Table 1.
Lead Author (Study Acronym), Publication Year | Design | Follow-up (years) | Daily Aspirin Regimen | Quality Score* |
---|---|---|---|---|
≤100 mg Aspirin Daily | ||||
Diener (ESPS-2), 2009 37 | RCT | 2 | 25 mg BID | 25 |
Ridker (WHS), 2005 38 | RCT | 10.1 (8.2–10.9) | 100 mg EOD | 24 |
Elwin (SALT), 1991 39 | RCT | 2.7 (1.3) | 75 mg | 25 |
Petersen (AFASAK), 1989 40 | RCT | 2 | 75 mg | 21 |
Hansson (HOT), 1998 7 | RCT | 3.8 (3.3–4.9) | 75 mg | 22 |
Feringa, 2009 48 | Cohort | 8.2 (5.1–10.9) | 80 mg | 12 |
Ogawa (JPAD), 2008 11 | RCT | 4.37 (4.35–4.39) | 81 or 100 mg | 22 |
Sacco (PPP–DM Subgroup), 2003 8 | RCT | 3.6 (2.7–4.2) | 100 mg | 21 |
Belch (POPADAD), 2008 12 | RCT | 6.7 (4.5–8.6) | 100 mg | 24 |
Catalano (CLIPS), 2007 41 | RCT | 1.7 ± 0.5 | 100 mg | 22 |
Fowkes (AAA), 2010 42 | RCT | 8.2 ± 1.6 | 100 mg | 24 |
McAlister–Low Dose, 2006 49 | Cohort | 1 | ≤100 mg | 12 |
Cubbon–Low Dose,2008 50 | Cohort | 2 | ≤100 mg | 11 |
Ong (FDS) Low Dose, 2010 51 | Cohort | 11.6 ± 2.9 | ≤100 mg | 14 |
101–325 mg Aspirin Daily | ||||
(PHS), 1989 6 | RCT | 5.0 (3.8–6.4) | 325 mg EOD | 22 |
Farrell (UK–TIA)–Moderate Dose, 1991 43 | RCT | 4 (1–7) | 300 mg | 22 |
McAlister–Moderate Dose, 2006 49 | Cohort | 1 | 101–325 mg | 12 |
Cubbon–Moderate Dose, 2008 50 | Cohort | 2 | 101–325 mg | 11 |
Ong (FDS) Moderate Dose, 2010 51 | Cohort | 11.6 ± 2.9 | 101–325 mg | 14 |
>325 mg Aspirin Daily | ||||
Peto (BMD), 1988 44 | RCT | 5.5 | 500 mg | 15 |
(ETDRS), 1992 9 | RCT | 5 (4–9) | 650 mg | 24 |
Elwood, 1979 45 | RCT | 1 | 300 mg TID | 17 |
(CDP Research Group), 1976 46 | RCT | 1.8 (0.8–2.3) | 324 mg TID | 19 |
Farrell (UK–TIA)–High Dose, 1991 43 | RCT | 4 (1–7) | 600 mg BID | 22 |
Cairns, 1985 47 | RCT | 1.5 | 325 mg QID | 20 |
McAlister–High Dose, 2006 49 | Cohort | 1 | >325 mg | 12 |
Cubbon–High Dose, 2008 50 | Cohort | 2 | >325 mg | 11 |
Ong (FDS) High Dose, 2010 51 | Cohort | 11.6 ± 2.9 | >325 mg | 14 |
*Downs & Black checklist of methodological quality (maximum score = 27)30
RCT=Randomized Controlled Trial; BID = Twice Daily; EOD = Every Other Day; TID = Three Times Daily; QID = Four Times Daily