Table 1. Polymorphism attempted validated in the present study.
| Gene | RS-number | P-values | Risk allele | Patients included | Phenotype | |
|---|---|---|---|---|---|---|
| Tan et al (2008) | SELP (selectin) | rs6136 | 0.000492 | C | 775 Patients with cancer at different sites and stages | 6 Phenotypes |
| LEPR (leptin receptor) | rs1137100 | 0.00821 | G | (1) >5% Weight loss | ||
| GHRL (ghrelin) | rs42451 | 0.006363 | T | (2) >10% Weight loss | ||
| TNFRSF1A (tumour necrosis factor receptor) | rs4149570 | 0.008415 | T | (3) >15% Weight loss | ||
| APEH (N-acylaminoacyl-peptide hydrolase) | rs4855881 | 0.000854 | C | (4–6) The above with CRP concentration of >10 mg l–1 | ||
| APEH (N-acylaminoacyl-peptide hydrolase) | rs2960548 | 0.00298 | G | |||
| Postfox01a (Forkhead box, sub-group O) | rs17446593 | 0.004702 | G | |||
| −129 SNPs were investigated | ||||||
| Deans et al (2009) | IL-10 (−1082) | rs1800896 | 0.014 | G | 203 Patients with gastro-oesophagal cancer | Weight loss >10% (80 patients) |
| −5 SNPs were investigated | 0.019 | |||||
| Zhang et al (2007) | IL-1β (+3954) | rs1143634 | 0.018 | T | 214 Patients with locally advanced gastric cancer | Weight loss > 10% (91 patients) |
| −4 SNPs were investigated | ||||||
| Jatoi et al (2007) | IL-1β (+3954) | rs1143634−4 SNPs were investigated | 0.02 | T | 44 Patients with metastatic gastric and gastro-oesophagal cancer | Phenotype is greater improvements in weight registered every 3 week during chemotherapy. |
Abbreviations: APEH=acylpeptide hydrolase; CRP=C-reactive protein; IL=interleukin; SNP=single-nucleotide polymorphism.