Table 4. Dominant model, the five most significant SNPs.
SNP | P-value; development sample (n=1204) | OR | B–H criterion | P-value; sample for confirmation (n=593) | OR |
---|---|---|---|---|---|
IRS1 (insulin receptor substrate) rs2234931 | 0.000045 | 1.88 | 0.00061 | 0.29184 | 0.44 |
LITAF (lipolysaccaride-induced tumour necrosis factor-α) rs4280262 | 0.013427 | 0.70 | 0.00123 | 0.00099 | 1.92 |
postfox01a (Forkhead box, sub-group O) rs1744659 | 0.024845 | 1.37 | 0.00184 | 0.95283 | 0.99 |
TTC18 (tetratricopeptide repeat domain 18) rs3812621 | 0.026004 | 0.65 | 0.00245 | 0.91230 | 1.03 |
IL-12β rs1368439 | 0.031608 | 2.12 | 0.00306 | 0.48657 | 1.26 |
Abbreviations: B–H=Benjamini–Hochberg; IL=interleukin; OR=odds ratio; SNP=single-nucleotide polymorphism.