Table 2. Comparison of association between immunohistochemical expression of GSTPi, vimentin or α-SMA in benign breast and paired cases of primary breast cancer or metastasis to axillary lymph nodes.
| Markers expression | Benign breast (n=11) | Primary breast cancer (n=39) | LN metastasis (n=39) | P-valuea | P-valueb |
|---|---|---|---|---|---|
| GSTPi expression in breast cells | <0.001 | <0.001 | |||
| Negative (%) | 0 (0) (0, 26)c | 29 (74) (58, 86)c | 30 (77) (60%, 88)c | ||
| Heterogeneous (%) | 0 (0) | 2 (5) | 1 (3) | ||
| Homogeneous (%) | 11 (100) | 8 (21) | 8 (21) | ||
| GSTPi expression in fibroblast | 1.00 | 0.33 | |||
| Negative (%) | 1 (9) (0, 40)c | 4 (10) (3, 25)c | 2 (5) (1, 19)c | ||
| Heterogeneous (%) | 0 (0) | 3 (8) | 7 (18) | ||
| Homogeneous (%) | 10 (91) | 32 (82) | 30 (77) | ||
| Vimentin expression in fibroblast | NA | 1.00 | |||
| Negative (%) | 0 (0) (0, 26)c | 0 (0) (0, 11)c | 0 (0) (0, 11)c | ||
| Heterogeneous (%) | 0 (0) | 0 (0) | 1 (3) | ||
| Homogeneous (%) | 11 (100) | 39 (100) | 38 (97) | ||
| Alpha-SMA expression in fibroblast | <0.001 | <0.001 | |||
| Negative (%) | 11 (100) (74, 100)c | 2 (5) (1, 19)c | 3 (8) (2, 22)c | ||
| Heterogeneous (%) | 0 (0) | 6 (15) | 1 (3) | ||
| Homogeneous (%) | 0 (0) | 31 (79) | 35 (90) | ||
Abbreviations: GSTPi=glutathione S-transferase Pi; α-SMA=α-smooth muscle actin; NA=not available.
a
P-value based on Fisher's exact test, comparing benign breast with primary beast cancer.
b
P-value based on Fisher's exact test, comparing benign breast with breast cancer metastasis to lymph node.
c
95% confidence intervals.