Table 2. Dose-limiting toxicities.

		Gefitinib	Number of patients		Type of DLT
Level	CPT-11 (mg m−2)	(mg per body weight)	Evaluable	DLT	(number of patients)
Level 1	50	250	3	0
Level 2	75	250	3	0
Level 3	100	250	6	2	Diarrhoea (2)
Level 4	125	250	3	0
Level 5	150	250	3	0

Abbreviations: CPT-11=irinotecan; DLT=dose-limiting toxicity.