Table 3. Toxicities in (a) first cycle; (b) all cycles.

(a)
	Level 1 (N=3)				Level 2 (N=3)				Level 3 (N=6)				Level 4 (N=3)				Level 5 (N=12)
NCI-CTC grade	1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4
Leucocytes	0	0	0	0	0	0	0	0	1	3	0	0	2	0	0	0	4	3	2	0
Neutrophils	0	0	0	0	0	0	0	0	3	0	1	0	1	0	0	0	2	3	3	1
Haemoglobin	3	0	0	0	1	1	0	0	3	1	0	0	2	0	0	0	5	2	1	0
Platelets	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0
General fatigue	0	0	0	0	0	1	0	0	3	0	0	0	1	0	0	0	3	1	0	0
Rash	3	0	0	0	3	0	0	0	4	0	0	0	1	0	0	0	4	1	0	0
Nausea/vomiting	1	0	0	0	1	1	0	0	4	0	0	0	2	1	0	0	8	4	0	0
Diarrhoea	1	1	0	0	2	0	0	0	2	0	2	0	1	2	0	0	6	3	2	0
Stomatitis	0	0	0	0	1	0	0	0	1	0	0	0	1	0	0	0	0	3	0	0
AST, ALT	1	0	0	0	2	0	0	0	1	2	0	0	1	0	0	0	5	2	0	0
Total bilirubin	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	3	1	0	0
Creatinine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0

(b)
	Level 1–4 (N=15)					Level 5 (N=12)					Total (N=27)
NCI-CTC grade	1	2	3	4	3–4(%)	1	2	3	4	3–4(%)	3–4(%)
Leucocytes	3	3	1	0	7	2	5	3	0	25	15
Neutrophils	2	2	3	0	20	2	1	5	2	58	37
Haemoglobin	9	5	0	0	0	7	3	1	0	8	4
Platelets	0	0	0	0	0	2	0	0	0	0	0
General fatigue	4	1	0	0	0	3	1	0	0	0	0
Rash	9	0	0	0	0	4	1	0	0	0	0
Nausea/Vomiting	8	2	0	0	0	8	4	0	0	0	0
Diarrhoea	5	4	2	0	13	5	4	2	0	17	15
Stomatitis	4	0	0	0	0	1	3	0	0	0	0
AST, ALT	5	2	0	0	0	5	2	0	0	0	0
Total bilirubin	2	0	0	0	0	4	2	0	0	0	0
Creatinine	0	0	0	0	0	4	0	0	0	0	0

Abbreviations: N=number of patients; AST=aspartate aminotransferase; ALT=alanine aminotransferase.