Table 1. Age range and family history of prostate cancer samples screened for BRCA2 germline mutation.
| Age range, years | Number of samples | With family history of PrCa (%) | With family history of Br/OvCa (%) | Percentage of samples deceased | Number of mutation carriers | Percentage of mutation carriers | Percentage of mutation carriers deceased |
|---|---|---|---|---|---|---|---|
| 36–55 | 632 (34.5%) | 34.5 | 25.3 | 15.3 | 8 | 1.27 | 37.5 |
| 56–65 | 957 (52.2%) | 50.6 | 24.3 | 12.4 | 11 | 1.15 | 81.8 |
| 66–88 | 243 (13.3%) | 100.0 | 29.6 | 29.8 | 0 | – | – |
| Total | 1832 | 51.6 | 25.4 | 15.7 | 19 | 1.03 | 63.2 |
Abbreviations: BrCa=breast cancer; OvCa=ovarian cancer; PrCa=prostate cancer.
A total of 1832 samples (age range 36–88) passed quality control, of which 1589 were aged ⩽65years at diagnosis. Protein-truncating mutations were enriched at younger age of diagnosis. Family history of BrCa and OvCa is also shown.