Figure 1.

Loss of CD34 expression leads to attenuated development of hypersensitivity pneumonitis (HP). (A) Total cells counts from bronchoalveolar lavage (BAL) of wild-type (wt) and Cd34^−/− mice challenged with either phosphate-buffered saline (PBS) or with the Saccharopolyspora rectivirgula (SR) antigen. (B) Frequency of macrophages, lymphocytes, and neutrophils in BAL of wt and Cd34^−/− mice. (C) Total number of macrophages, lymphocytes, and neutrophils in BAL of wt and Cd34^−/− mice challenged with PBS or the SR antigen. (A–C) Data are presented as mean ± SEM and are representative of four independent experiments. (D) IFN-γ production by lung inflammatory cells in response to the SR antigen. Data are representative of three separate recall experiments. *P < 0.05, n = 6–7 mice per group.