Figure 2.

Histological analysis of lungs from wild-type (wt) and Cd34^−/− mice challenged with phosphate-buffered saline (PBS) or the Saccharopolyspora rectivirgula (SR) antigen. (A) Hematoxylin and eosin–stained lung sections obtained from wt and Cd34^−/− mice challenged intranasally with PBS or the SR antigen. PA = parenchymal infiltrate; PB = peribronchial infiltrate; PV = perivascular infiltrate; TD = tissue damage. (B) Histological score obtained in four animals, in which the following parameters were evaluated on a scale of 1 to 4 (naive to most severe): parenchymal infiltrate, perivascular infiltrate, peribronchial infiltrate, tissue damage, presence of granulomas, and all of the above combined for the total histological score. Data are presented as mean ± SEM, and are representative of two separate experiments. n = 4 mice per group.