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. 2011 Nov 4;6(11):e27180. doi: 10.1371/journal.pone.0027180

Figure 1. Direct leptin to the rat VTA induced phosphorylation events.

Figure 1

Regulation of various Lepr pathways was evaluated 45 minutes after direct leptin infusion to the VTA of cannulated awake adult male rats. Ratios of phospho-/total signal were used to calculate the percent change from control tissue. Blots shown are representative. Open bars represent vehicle while black bars represent leptin treatment. A. pSTAT3 (Tyr-705) (n = 4) *, (P = 0.0077). B. pERK1/2 (Thr-202, Tyr-204) (n = 4) *, (P = 0.0252). C. pAKT (Ser-473) (n = 4). D. pAKT (Thr-308) (n = 4).