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. 2011 Nov 4;6(11):e27180. doi: 10.1371/journal.pone.0027180

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Trinko et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Direct leptin infusion to the VTA of rats caused a significant decrease in food intake, while pretreatment with U0126 ICV blocked this effect. Treatment groups include: vehicle^ICV/vehicle^VTA (open bars; n = 13), U0126^ICV/vehicle^VTA (open-striped bars; n = 11), vehicle^ICV/Leptin^VTA (gray bars; n = 12), U0126^ICV/Leptin^VTA (gray-striped bars; n = 13). * Represents significant effect of leptin (F_{(1, 45)} = 7.78, P<0.008). ^# Represents significant Leptin-U0126 interaction (F_{(1, 45)} = 4.17, P<0.047).