TABLE 1.

CONCENTRATIONS OF TOTAL IMMUNOGLOBULIN E AND OVALBUMIN-SPECIFIC ANTIBODIES IN THE SERUM^*

	PBS/OVA/vehicle	PBS/OVA/ BLT1i	OVA/OVA/vehicle	OVA/OVA/ BLT1i6
Total IgE, ng/ml	1814 ± 390†	1618 ± 483	4101 ± 358‡	4167 ± 565‡
OVA-specific IgE, mU/ml	<10	<10	30.6 ± 9.0‡	26.8 ± 8.8‡
OVA-specific IgG1, EU/ml	<10	<10	1681 ± 119‡	1524 ± 97‡

Definition of abbreviations: mU/ml = ELISA mUnits/ml; OVA/OVA/BLT1i = sensitized and challenged mice followed by treatment with BLT1 antagonist; OVA/OVA/vehicle = sensitized and challenged mice followed by vehicle treatment; PBS/OVA/BLT1i = nonsensitized but challenged mice followed by treatment with BLT1 antagonist; PBS/OVA/vehicle = nonsensitized but challenged mice followed by treatment with vehicle.

^*Mice were sensitized and challenged as described in Materials and Methods. Serum levels of immunoglobulins were assessed 48 h after the last challenge.

^†Mean ± SEM.

^‡P < 0.05. PBS/OVA/vehicle PBS/OVA/BLT1i vs. OVA/OVA/vehicle OVA/OVA/BLT1i (n = 12 in each group).