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. 2011 Nov 4;6(11):e27355. doi: 10.1371/journal.pone.0027355

Figure 5. Dysregulation of important indicators of metastasis, prognosis and hormone receptors after treatment.

Figure 5

A) Regulation of PDCD4 and CXCR4 genes as important indicators of metastasis and prognosis before and after treatment in two studied cancerous cell lines. a1-2) Expression profiles of PDCD4 and CXCR4 genes and regulatory microRNAs in MDA-MB231 and SKBR3 cell lines, respectively. a3) Pathway analysis predicts the role of PDCD4 and CXCR4 in cancerogenesis and shows the upstream regulatory miRNAs. B) Mechanism of ERBB2 receptor down-regulation in SKBR3 (non-aggressive breast cancer cell line). b1) Pathway analysis shows negative upstream regulators of ERBB2 gene and PDIA6 as an example of positive regulators. b2) Expression profiles of ERBB2 and some negative regulators (BRCA1, MYC and miR-125b) that demonstrated significant changes during treatment. b3) Expression profile of Pdia6 protein as a positive regulator of ERBB2 that is detected by proteomics analysis.