Figure 1. Library of signature motifs mapped to the V3 regions of AIDSVAX immunogens.

Signature motifs recognized by each monoclonal antibody are shown in the second column: the numbers indicate the recognized positions in the V3 loop and the letters indicate the amino acid residues at each position required for recognition by that monoclonal antibody. Positions numbering is in the correspondence with the standard V3 loop numbering described elsewhere [19], [20]. Colored rectangles in the sequence column indicate the amino acid residues composing the signature motif in each of the gp120s. Sequences without colored rectangles do not contain a given motif.