Table 2. PCOS phenotype for PA adult monkeys.
Monkeys | Menstrual cycles (mean duration in days) | Ovarian morphology | Testosterone (ng/ml) |
Adult controls | |||
#1 | Normal (26) | NA | 0.12 |
#2 | Normal (28) | NA | 0.20 |
#3 | Normal (NA) | NA | 0.21 |
#4 | Normal (27) | NA | 0.27 |
#5 | Normal (26) | NA | NA |
PA adults | |||
#1 | Normal (31) | PCO | NA |
#2 | Intermittent/anovulatory (43) | PCO | 0.20 |
#3 | Intermittent/anovulatory (93) | Normal | 0.32 |
#4 | Intermittent/anovulatory (70) | PCO | 0.48 |
#5 | Intermittent/anovulatory (48) | Normal | 0.40 |
#6 | Intermittent/anovulatory (52) | PCO | 0.51 |
#7 | Intermittent/anovulatory (120) | PCO | 0.29 |
#8 | Intermittent/anovulatory (35) | PCO | 0.37 |
PA female rhesus monkeys exhibit a variety of phenotypes similar to those found in PCOS women. PA monkey phenotypes were refined from those previously described [61], [62]; intermittent/anovulatory cycles were defined as cycle lengths longer than 34 days because 92% of normal female rhesus monkeys have menstrual cycles between 24–34 days [63]; hyperandrogenism was defined as testosterone ≥0.32 ng/ml, which represents the mean plus one standard deviation in circulating basal testosterone levels of control monkeys [62]. PCO: polycystic ovary morphology, determined from photos taken via laparoscope during transabdominal illumination; PCO was defined as the presence of 10 or more ∼1–3 mm follicles per greatest ovarian diameter [64]. NA: not available or not assessed.