Table 3. Correlation coefficients for reaction pairs were obtained for simulated wild type, engineered cofactor imbalanced and engineered cofactor balanced models.
| Reactions | Reactions | Wild type model | Engineered cofactor imbalanced model | Engineered cofactor balanced model |
| PGK | PYRDC | -0.50 | -0.93 | -0.32 |
| PGK | GLYCDy | -0.07 | -0.53 | -0.13 |
| PGK | G3PT | -0.06 | -0.53 | -0.12 |
| PGK | G3PD1ir | -0.01 | -0.39 | -0.09 |
| PGK | ENO | -0.92 | -1.00 | -0.92 |
| PGK | DHAK | -0.07 | -0.53 | -0.13 |
| PGK | PYK | -0.85 | -0.99 | -0.87 |
| PGM | PYRDC | -0.45 | -0.93 | -0.34 |
| PGM | GLYCDy | -0.09 | -0.53 | -0.06 |
| PGM | G3PT | -0.08 | -0.53 | -0.05 |
| PGM | G3PD1ir | -0.01 | -0.39 | -0.03 |
| PGM | DHAK | -0.09 | -0.53 | -0.06 |
| PYRDC | GAPD | 0.50 | 0.93 | 0.32 |
| PYRDC | GLYCDy | 0.04 | 0.51 | 0.22 |
| PYRDC | G3PT | 0.04 | 0.51 | 0.22 |
| PYRDC | G3PD1ir | -0.05 | 0.35 | 0.17 |
| PYRDC | ENO | 0.45 | 0.93 | 0.34 |
| PYRDC | DHAK | 0.04 | 0.51 | 0.22 |
| PYRDC | PYK | 0.43 | 0.93 | 0.31 |
| GAPD | GLYCDy | 0.07 | 0.53 | 0.13 |
| GAPD | G3PT | 0.06 | 0.53 | 0.12 |
| GAPD | G3PD1ir | 0.01 | 0.39 | 0.09 |
| GAPD | DHAK | 0.07 | 0.53 | 0.13 |
| GLYCDy | G3PD1ir | 0.89 | 0.47 | 0.89 |
| GLYCDy | ENO | 0.09 | 0.53 | 0.06 |
| GLYCDy | PYK | 0.13 | 0.53 | 0.06 |
| G3PT | G3PD1ir | 0.89 | 0.46 | 0.89 |
| G3PT | ENO | 0.08 | 0.53 | 0.05 |
| G3PT | PYK | 0.12 | 0.52 | 0.06 |
| G3PD1ir | ENO | 0.01 | 0.39 | 0.03 |
| G3PD1ir | DHAK | 0.89 | 0.47 | 0.89 |
| G3PD1ir | PYK | 0.08 | 0.39 | 0.03 |
| ENO | DHAK | 0.09 | 0.53 | 0.06 |
| DHAK | PYK | 0.13 | 0.53 | 0.06 |
Engineered cofactor imbalanced model has shown higher correlation coefficient between reaction pairs compared to wild type and cofactor balanced models.