Table 1. Most important gray and adjacent white matter regions discriminating between heavy smokers and controls.

Lobe	Brain Regions	Wi	MNI Coordinates
			X	Y	Z
	Gray Matter
	Nonsmokers minus smokers
Frontal lobe	Frontal subgyral	7.25	−38	12	24
	Superior Frontal Gyrus	8.35	28	42	16
	Precentral Gyrus	9.25	14	−28	72
	Anterior Cingulate	5.47	−14	46	6
Temporal lobe	Cortex	7.36	44	−50	−12
Parietal lobe	Fusiform Gyrus	7.81	−38	−52	34
	Supramarginal Gyrus	8.19	−10	−42	34
Occipital lobe	Precuneus	11.01	24	−88	12
Other	Middle Occipital Gyrus	8.38	−28	−40	−46
	Cerebellum Tonsil	7.40	28	−40	−50
	Gray Matter
	Smokers minus nonsmokers
Frontal lobe	Postcentral Gyrus	6	46	−24	42
Temporal lobe	Superior Temporal	5.73	60	−20	0
Parietal lobe	Gyrus	6.24	−22	−78	30
	Cuneus	6.52	−26	−65	−2
Occipital lobe	Lingual Gyrus	6.06	18	6	−20
Other	Parahippocampa Gyrus	6.04	−10	−32	−36
	Pons	6.39	2	−58	4
	Posterior Cingulate
	cortex
	White Matter
	Nonsmokers minus smokers
Frontal lobe	Medial Frontal Gyrus	6.10	−12	44	32
		7.03	24	36	34
Temporal Gyrus	Inferior Temporal	7.78	−40	−12	−34
Parietal lobe	Gyrus	11.03	−28	−60	34
	Precuneus	8.25	24	−80	−8
Occipital lobe	Lingual Gyrus	8.15	−28	−62	−4
Other	Middle Occipital Gyrus	6.86	−22	−56	−46
	Cerebellar Tonsil	9.99	−10	−32	−38
	Pons
	White Matter
	Smokers minus nonsmokers
Frontal lobe	Anterior Cingulate	7.30	−12	44	6
	Cortex	7.45	−10	−42	−2
Temporal lobe	Midcingulate Cortex/	9.53	44	−50	16
Parietal Lobe	Superior Temporal	8.93	34	−42	40
Occipital lobe	Cortex	9.71	28	−86	12
Other	Inferior Parietal Cortex	5.62	22	18	52
	Middle Occipital Gyrus	5.72	−20	18	−4
	Putamen

W_i, weight of each cluster centroid i.