TABLE 3.

RISK RATIOS FOR THE ASSOCIATION BETWEEN PREOPERATIVE BODY MASS INDEX AND GRADE 3 PRIMARY GRAFT DYSFUNCTION WITHIN 72 HOURS STRATIFIED BY DIAGNOSIS AND USE OF CARDIOPULMONARY BYPASS

		BMI Category				Continuous BMI
	No.	BMI <25 kg/m2	BMI 25–29.9 kg/m2	BMI ≥ 30 kg/m2	P Trend	Risk Ratio (95% CI) per 5 kg/m2 Increase	P Value	P for Interaction
Stratified by use of CBP
CBP	137	1 (Ref)	1.6 (1.2–2.1)	1.5 (1.3–1.7)	<0.001	1.2 (1.02–1.5)	0.03	0.08
No CBP	375	1 (Ref)	2.1 (1.3–3.5)	2.7 (1.9–4)	<0.001	1.5 (1.3–1.7)	<0.001
Stratified by diagnosis
COPD only	261	1 (Ref)	2 (1.3–3)	2.4 (1.1–5)	0.01	1.4 (1.1–1.8)	0.006	0.40
ILD only	251	1 (Ref)	1.8 (1.2–2.7)	1.8 (1.1–2.8)	0.002	1.3 (1.2–1.5)	<0.001

Definition of abbreviations: BMI = body mass index; CBP = cardiopulmonary bypass; CI = confidence interval; COPD = chronic obstructive pulmonary disease; ILD = interstitial lung disease; PGD = primary graft dysfunction.

Effect estimates are risk ratios (95% confidence intervals). Models are adjusted for transplant procedure (bilateral vs. single), systolic pulmonary artery pressure, ischemic time, donor oxygenation, and donor age with a random intercept for study center. Models stratified by cardiopulmonary bypass are adjusted for diagnosis. Models stratified by diagnosis are adjusted for use of cardiopulmonary bypass.