TABLE 2.

ASSOCIATIONS OF DELAY WITH SURVIVAL AND LUNG TRANSPLANTATION IN IDIOPATHIC PULMONARY FIBROSIS

	Quartile of Delay					Hazard Ratio (95% CI) per Log2(time)*
	<1 yr	1–2 yr	2–4 yr	>4 yr	P Value for Trend		P Value
No.	33	32	33	31
Person-years†	48.1	38.7	41.0	40.7
Survival
Mortality rate‡	8.3	18.1	26.8	31.9
Unadjusted hazard ratio	Ref.	1.9	2.6	3.3	0.04	1.3 (1.02–1.6)	0.03
Model 1 hazard ratio§	Ref.	2.0	2.8	3.6	0.03	1.3 (1.03–1.6)	0.03
Model 2 hazard ratio‖	Ref.	2.0	2.5	3.4	0.04	1.3 (1.03–1.6)	0.03
Transplantation
Transplantation rate‡	18.7	31.0	24.4	22.1
Unadjusted hazard ratio	Ref.	1.5	1.0	0.8	0.31	NA
Model 1 hazard ratio§	Ref.	1.5	0.9	0.8	0.33	NA
Model 2 hazard ratio‖	Ref.	1.6	1.1	1.0	0.68	NA

Definition of abbreviations: CI = confidence interval; NA = not applicable (nonlinear association); Ref. = reference.

^*Represents the hazard ratio for each doubling of delay.

^†Censored at transplantation.

^‡Per 100 person-years.

^§Model 1 = adjusted for age, sex, and FVC % predicted.

^‖Model 2 = adjusted for age, sex, FVC % predicted, private insurance, and college education.