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. 2011 Nov;96(11):1580–1588. doi: 10.3324/haematol.2011.042515

Figure 1.

Figure 1.

Bone marrow hypoplasia and osteomyelosclerosis in aged NFATc2−/− mice. (A) Femora of young and aged wild-type (WT) and NFATc2 knock-out (KO) mice. Note that femora of aged KO mice appear pale compared to WT bones. (B) Numbers of bone marrow cells extracted from young and old WT and KO femora. (C) Bone marrow differentials. The numbers of erythroblasts, granulocytic cells, lymphocytes and megakaryocytes extracted from aged WT and KO femora are shown. Results are presented as means ± SEM. *P<0.05; **P<0.01; ***P<0.001. (D) Hematoxylin-eosin staining of femoral sections from an aged WT and KO mouse pair (a, c: WT; b,d: KO). Note the highly ossified bone marrow space in the KO femur. (E) Gomori staining of femoral sections from an aged WT and KO mouse pair (a, c: WT; b,d: KO). Note the presence of reticular fibers only in the KO bone marrow. Magnification, a,b: 100x; inserts c,d: 400x.