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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Virology. 2011 Oct 5;421(1):19–27. doi: 10.1016/j.virol.2011.09.014

Figure 4.

Figure 4

Erlotinib stimulates premature senescence in cells that fail to undergo apoptosis. Cells were infected with retroviruses encoding HPV-16 E6 and E7 and cultured in KSFM with 1.0 μM erlotinib for up to 14 days. At intervals of 2 days, triplicate cultures were removed from the drug and fed with KSFM for an additional 10 days to allow colony formation. Triplicate cultures were stained for β-galactosidase. Symbols represent the mean and bars indicate ± standard deviation.