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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Virology. 2011 Oct 5;421(1):19–27. doi: 10.1016/j.virol.2011.09.014

Table 2.

Frequency of immortalization of human cervical cells by HPV-16 E6/E7 genes or by SV40 after treatment with erlotinib.

Erlotinib HCX4 - E6/E7 HCX5 - E6/E7 HCX6 - E6/E7 HCX7 - SV40
untreated 5/51 6/6 6/6 6/6
0.1 μM 4/6 4/6 5/6 5/6
0.3 μM 3/6 2/6 2/6 4/6
1.0 μM 0/6 0/6 0/5 0/5
3.0 μM 0/4 0/6 0/6 0/6
1

Number of wells with immortal cells/total number of wells examined. Each column represents an independent experiment using cells from a different sample of cervix. All experiments were performed in KSFM plus 5 ng/ml EGF.