Table 3.

Crude and Adjusted Odds Ratios and 95% Confidence Intervals for mtDNA Copy Number and Pancreatic Cancer Risk

		mtDNA Copy Number
	Q1 ≤94.6	Q2 >94.6-≤113.3	Q3 >113.3-≤132.8	Q4 >132.8-≤158.0	Q5 >158.0	p- trend†	Continuous OR‡
n (cases/controls)	38/133	39/133	30/142	43/130	53/118		203/656
Crude	1.00 (ref)	1.03 (0.62-1.71)	0.74 (0.43-1.26)	1.16 (0.70-1.91)	1.57 (0.97-2.55)	0.06	1.13 (1.05-1.22)
Adjusted§	1.00 (ref)	1.04 (0.63-1.74)	0.75 (0.44-1.28)	1.22 (0.74-2.02)	1.64 (1.01-2.67)	0.04	1.14 (1.06-1.23)
Cases diagnosed <7 years after whole blood collection
n (cases/controls)	38/118	23/130	13/142	21/133	23/133		118/656
Crude	1.00 (ref)	0.91 (0.48-1.73)	0.53 (0.26-1.10)	1.02 (0.55-1.91)	1.86 (1.05-3.31)	0.05	1.13 (1.05-1.22)
Adjusted§	1.00 (ref)	0.78 (0.38-1.59)	0.60 (0.28-1.27)	1.16 (0.59-2.27)	2.14 (1.16-3.96)	0.01	1.21 (1.10-1.34)
Cases diagnosed ≥7 years after whole blood collection	15/118	20/130	17/142	18/133	15/133		85/656
Crude	1.00 (ref)	1.20 (0.58-2.48)	1.06 (0.51-2.21)	1.36 (0.67-2.78)	1.13 (0.53-2.40)	0.06	1.03 (0.92-1.16)
Adjusted§	1.00 (ref)	1.27 (0.61-2.63)	1.08 (0.52-2.27)	1.37 (0.67-2.81)	1.14 (0.53-2.45)	0.67	1.05 (0.93-1.18)

^†Test for trend calculated using the median value for each mtDNA copy number quintile

^‡Continuous variables are presented based on a 21 unit change, which corresponds to the average unit change within quintiles 2-4.

^§Adjusted for age, smoking duration, smoking intensity, diabetes