. Author manuscript; available in PMC: 2012 Dec 1.

Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2011 Aug 31;85(6):335–343. doi: 10.1016/j.plefa.2011.08.005

TABLE 5.

Selected LCPUFA of hippocampus, globus pallidus and inferior colliculus from piglets fed varying levels of ARA and DHA from days 3 – 28 of age¹

Diet ARA/DHA²	A1 0.09/1.00	A2 0.53/1.02	A3–D3 0.69/1.01	A4 1.06/1.04	D2 0.67/0.62	D1 0.66/0.33	MR 0.74/0.01	P
Hippocampus	% total FA
ARA	10.40 ± 0.89	10.78 ± 0.93	10.57 ± 1.09	10.61 ± 1.57	11.10 ± 0.97	10.85 ± 1.23	11.77 ± 0.96	NS
22:4n-6	4.57 ± 0.36	4.68 ± 0.43	4.63 ± 0.57	4.72 ± 0.63	4.78 ± 0.44	5.03 ± 0.51	5.37 ± 0.43	NS
22:5n-6	2.89 ± 0.22^a	2.96 ± 0.39^a	3.06 ± 0.39^ab	2.68 ± 0.67^b	3.71 ± 0.40^c	3.31 ± 0.53^ac	5.58 ± 0.60^d	<.0001
22:5n-3	0.24 ± 0.03^ab	0.22 ± 0.05^bc	0.22 ± 0.02^bc	0.20 ± 0.05^bc	0.19 ± 0.02^c	0.24 ± 0.04^ab	0.27 ± 0.04^a	0.009
DHA	9.89 ± 0.26^a	9.74 ± 1.43^a	9.66 ± 0.68^ab	9.63 ± 1.73^a	9.44 ± 1.03^a	8.27 ± 1.48^b	6.12 ± 0.68^c	0.0002
Σ 22C LCPUFA³	17.20 ± 1.41	17.60 ± 1.87	17.13 ± 1.99	17.23 ± 2.89	18.12 ± 1.44	16.84 ± 2.23	17.34 ± 0.64	NS
Globus pallidus
ARA	10.33 ± 0.68	9.33 ± 1.28	10.07 ± 0.44	9.92 ± 0.76	10.02 ± 0.88	10.09 ± 0.96	10.73 ± 0.82	NS
22:4n-6	3.81 ± 0.32^ab	3.59 ± 0.73^b	4.25 ± 0.51^bc	3.98 ± 0.87^ab	3.72 ± 0.37^ab	4.04 ± 0.58^ab	4.78 ± 0.65^c	0.02
22:5n-6	2.93 ± 0.37^a	2.24 ± 0.77^b	2.81 ± 0.40^ab	2.64 ± 0.58^ab	3.16 ± 0.73^a	3.04 ± 0.78^a	5.40 ± 0.92^c	<.0001
22:5n-3	0.15 ± 0.12	0.12 ± 0.04	0.13 ± 0.03	0.13 ± 0.02	0.11 ± 0.04	0.14 ± 0.06	0.19 ± 0.06	NS
DHA	9.45 ± 0.97^a	8.09 ± 2.61^ab	8.80 ± 0.94^ab	8.18 ± 1.36^ab	7.91 ± 1.95^b	7.66 ± 1.68^bc	6.08 ± 0.35^c	0.01
Σ 22C LCPUFA	16.74 ± 1.12	14.49 ± 3.72	16.44 ± 1.37	15.41 ± 2.20	15.37 ± 2.68	15.34 ± 2.50	16.92 ± 1.43	NS
Inferior colliculus
ARA	8.58 ± 0.35	8.55 ± 0.75	8.85 ± 0.84	8.61 ± 0.52	8.63 ± 0.50	8.97 ± 0.73	9.45 ± 1.25	NS
22:4n-6	3.54 ± 0.21^a	3.36 ± 0.19^a	3.55 ± 0.31^a	3.56 ± 0.29^a	3.42 ± 0.30^a	3.70 ± 0.35^a	4.68 ± 1.16^b	<.0001
22:5n-6	1.58 ± 0.49^ab	1.50 ± 0.35^a	1.60 ± 0.45^ab	1.62 ± 0.52^ab	1.93 ± 0.53^b	1.91 ± 0.32^b	3.76 ± 0.45^c	<.0001
22:5n-3	0.19 ± 0.02^ab	0.18 ± 0.04^abc	0.19 ± 0.04^ab	0.15 ± 0.02^c	0.16 ± 0.03^bc	0.18 ± 0.03^bc	0.21 ± 0.06^a	0.02
DHA	10.71 ± 0.94^a	10.32 ± 1.88^a	10.84 ± 1.50^a	9.58 ± 1.21^a	10.18 ± 1.27^a	10.53 ± 0.85^a	6.27 ± 1.14^b	<.0001
Σ 22C LCPUFA	16.35 ± 1.10	15.66 ± 2.18	16.46 ± 2.03	15.28 ± 1.60	16.02 ± 1.46	16.61 ± 1.23	15.40 ± 1.74	NS

Values represent mean ± SD, n = 8 per diet. P < 0.05 indicates that all means were not equal; NS, not significant. Pairwise comparisons determined using Student's t-test; means not sharing a common superscript were significantly different (P < 0.05).

ARA/DHA, dietary content of ARA/DHA (% FA/FA).

Σ 22C LCPUFA = Σ 22:3(n-9), 22:4n-6, 22:5n-6, 22:5n-3, DHA.