Table 3.

Summary of the changes in gene expression for phenotypic groups by our Mechanical Panel of stimulation

Gene group	Cyclic pressure (h)		Shear stress (h)		Cyclic stretch (h)
	24	72	24	72	24	72
Muscle	↓	↓	↓	↓↓	↓	↑↑
Endothelial	↑	↑	↑	↑	↓	↔
Bone	↔	↑	↑↑	↔	↑	↑↑
Cartilage	↑↑	↑	↔	↓	↑	↑
Fat	↔	↔	↔	↑	↔	↔
Growth Factor	↑↑	↔	↑↑	↑↑	↔	↔
ECM	↑↑	↔	↑↑	↑	↓	↑
Proliferation	↓↓	↔	↓↓	↓↓	↔	↑↑

To give some global sense to the data, a change index (CI) was calculated by averaging a score of 0 for no change, ±1 for a biological or statistical (p < 0.1) trend, and ±2 for a biologically relevant and statistically significant (p < 0.05) change for each of the genes in that category. ↑↑ and ↓↓ indicate a majority increase or decrease (CI > 0.70)in the overall gene expression for that group from control values. Single arrows denote a moderate change (0.25 ≤ CI ≤ 0.70) in the majority of the genes for a particular phenotype, and ↔ indicates very little change (CI < 0.25)