Table 3.

LINE-1 levels in relation to risk of bladder cancer, The Shanghai Bladder Cancer Case-Control Study

	LINE1 in tertiles among total subjects			Ptrend
	1st (82.52+)	2nd (81.22-<82.52)	3rd (<81.22)
Total Subjects
No. cases/no. controls	154/177	165/176	191/175
OR (95% CI) *	1.00 (reference)	1.10 (0.81–1.50)	1.28 (0.95–1.73)	0.268
By gender
Men
No. cases/no. controls	132/143	134/143	134/119
OR (95% CI) *	1.00 (reference)	1.03 (0.73–1.42)	1.23 (0.87–1.73)	0.455
Women
No. cases/no. controls	22/34	31/33	57/56
OR (95% CI) *	1.00 (reference)	1.57 (0.74–3.31)	1.58 (0.82–3.04)	0.360
By smoking status at reference date
Nonsmokers
No. cases/no. controls	40/75	50/74	88/87
OR (95% CI) *	1.00 (reference)	1.34 (0.79–2.28)	1.91 (1.17–3.13)	0.032
Former smokers
No. cases/no. controls	25/33	32/31	22/25
OR (95% CI) *	1.00 (reference)	1.37 (0.66–2.83)	1.10 (0.50–2.43)	0.682
Current smokers
No. cases/no. controls	89/69	83/71	81/63
OR (95% CI) *	1.00 (reference)	0.93 (0.59–1.45)	0.99 (0.63–1.56)	0.938

^*All odds ratios (ORs) were adjusted for age at reference date (continuous) and family history of cancer (yes/no); regression models for total subjects and by smoking status were also adjusted for gender (male/female); regression models for nonsmoking subjects at reference date were also adjusted for ETS exposure status (yes/no).