Table 4.
LINE1 levels in relation to risk of bladder cancer by GSTM1 and GSTT1 genotypes, The Shanghai Bladder Cancer Case-Control Study
| LINE1 in tertiles among total subjects
|
Ptrend | |||
|---|---|---|---|---|
| 1st (82.52+) | 2nd (81.22-<82.52) | 3rd (<81.22) | ||
| By GSTM1/GSTT1 genotypes | ||||
| Both Non-null genes | ||||
| No. cases/no. controls | 30/23 | 30/40 | 35/50 | |
| OR (95% CI) | 1.00 (reference) | 0.60 (0.28–1.25) | 0.51 (0.25–1.04) | 0.169 |
| One or both null genes | ||||
| No. cases/no. controls | 123/153 | 132/135 | 151/123 | |
| OR (95% CI) | 1.00 (reference) | 1.23 (0.87–1.72) | 1.58 (1.12–2.22) | 0.054 |
| One null gene only | ||||
| No. cases/no. controls | 73/99 | 70/96 | 90/77 | |
| OR (95% CI) | 1.00 (reference) | 1.02 (0.66–1.58) | 1.66 (1.07–2.57) | 0.037 |
| Both null genes | ||||
| No. cases/no. controls | 50/54 | 62/39 | 61/46 | |
| OR (95% CI) | 1.00 (reference) | 1.65 (0.94–2.90) | 1.49 (0.85–2.59) | 0.175 |
| Lifelong nonsmokers with one Or both null genes | ||||
| No. cases/no. controls | 31/60 | 38/59 | 70/58 | |
| OR (95% CI) | 1.00 (reference) | 1.26 (0.69–2.29) | 2.36 (1.34–4.14) | 0.006 |
*
All odds ratios (ORs) were adjusted for age at reference date (continuous) and family history of cancer (yes/no); regression models for total subjects and by smoking status were also adjusted for gender (male/female); regression models for nonsmoking subjects at reference date were also adjusted for ETS exposure status (yes/no).