TABLE 3.
Summary features for 11 Group 4 patients; APAP adduct assay negative.
| 1 | 2 | 3 | 4 | 5 | 6 | 7† | 8 | 9 | 10 | 11 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, years | 28 | 76 | 41 | 40 | 43 | 52 | 43 | 33 | 43 | 37 | 42 |
| Gender | F | F | M | M | F | F | M | F | F | M | M |
| Overdose Type | S | A | S | U | A | A | S | S | S | A | S |
| APAP Dose, gm | - | - | 40 | - | - | 84 | 31.5 | 75 | 19.5 | - | - |
| APAP Level | 0 | - | 186 | - | 10 | 0 | - | 0 | 31 | 0 | 232 |
| Alcohol Use | N | N | Y | Y | Y | N | Y | Y | N | Y | - |
| Symptom to Coma Duration, days | 5 | 4 | 3 | 1 | 1 | 14 | 14 | 8 | 5 | 5 | 0 |
| Late Presenter | Y | N | N | N | N | Y | Y | Y | Y | Y | N |
| ALT, IU/L | 1154 | 576 | 13110 | 3779 | 9386 | 629 | 136 | 1810 | 621 | 4030 | 9810 |
| AST, IU/L | 485 | 1808 | 18710 | 10860 | 17780 | 862 | 129 | 170 | 277 | 3899 | 6910 |
| Bilirubin, mg/dL | 7.8 | 1.4 | 10 | 0.7 | 0.7 | 34.6 | 22.9 | 11.1 | 7.3 | 6 | 4.8 |
| APAP-adducts, nmol/mL | .207 | .632 | .246 | .342 | .294 | .157 | .010 | .335 | .446 | .019 | .244 |
| MELD score | 30.2 | 10.6 | 41.9 | 34.9 | 29.1 | 46.2 | 33.5 | 38.1 | 19.2 | 44.9 | 41.6 |
| APAP King’s Criteria met | N | N | N | N | N | N | N | N | N | N | Y |
| Hepatic Coma Grade | 4 | 2 | 1 | 4 | 3 | 3 | 1 | - | 3 | 3 | 4 |
| Ventilated | Y | Y | Y | Y | Y | Y | N | Y | Y | Y | Y |
| Any NAC Treatment | Y | Y | Y | Y | Y | Y | N | N | Y | Y | Y |
| OLTx day # | 3 | 5 | |||||||||
| Death, day # | 5 | 28 | 9 | 5 |
If not listed as died or transplanted, the remaining patients survived without transplantation.
Dashes indicate information not available.
†
Subsequent assessment: probable autoimmune hepatitis leading to acute liver failure.
S= Suicidal, A=Accidental/Unintentional, U=Unknown