Table 2.
Abbreviations: ADAS-cog = cognitive component of the Alzheimer's Disease Assessment Scale; BPRS = Brief Psychiatric Rating Scale; CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; GCS = Glasgow Coma Scale; GIC = Global Impression of Change; IPD = inherited prion disease; MMSE = Mini-Mental State Examination; sCJD = sporadic Creutzfeldt-Jakob disease; vCJD = variant Creutzfeldt-Jakob disease.
Test for difference between slow, medium, and fast progressors. Mean baseline and annual rates of decline were estimated from mixed models including observed data only (without imputation) with random intercept and slope for each participant. SD = sqrt(n) × SE (mean annual rate of decline).
Sample size estimates were based on 80% power, and a 2-sided significance level 5%. The severity stratified models were restricted to patients with baseline Rankin 2–3 or 2–4. In the imputed model the worst score was imputed for death (except for BPRS, see appendix e-1) and any subsequent scores after a patient recorded the worst score were discarded.