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. 2011 Nov;77(22):8097–8105. doi: 10.1128/AEM.05316-11

Table 4.

Expression of virulence factors of S. aureus grown in TSB, CDM(−), and CDM(−) with 3 μM FeCl3

GeneIDa Gene name Function TSB expressionb CDM(−)
 CDM(−) + 3 μM FeCl3
Expressionb Fold change (TSB)c Expressionb Fold change [CDM(−)]d
RNAIII Global regulon 1.41 1942.26 1377.53** 31.66 0.02+++
MW1044 hla Hemolysin 1.72 5.76 3.35* 1.80 0.31
MW2342 hlgA Hemolysin 0.25 0.86 3.48* 0.25 0.29+
MW1942 lukM Leukocidin 4.63 9.31 2.01* 2.80 0.30+++
MW1767 lukD Leukocidin 0.21 0.54 2.57* 0.23 0.43++
MW1379 lukS-PV Leukocidin 1.73 2.71 1.56 0.95 0.35+++
psmα Phenol-soluble modulin 0.88 111.72 126.74* 2.97 0.03+
MW1056 psmβ1 Phenol-soluble modulin 1.44 2380.99 1657.47** 46.09 0.02++
MW0759 sec4 Enterotoxin 5.16 177.22 34.35*** 21.86 0.12++
MW1889 sea Enterotoxin 2.41 4.67 1.94** 1.56 0.34+
MW2558 aur Protease 0.87 1.24 1.43* 0.40 0.32++
MW0932 sspA Protease 0.69 1.40 2.04** 0.56 0.40++
MW1755 splA Protease 0.25 0.82 3.25* 0.35 0.42++
MW0297 geh Lipase 1.21 5.26 4.33*** 1.72 0.33++
MW0206 coa Coagulase 3.51 7.29 2.08** 3.90 0.53+
MW1885 sak Staphylokinase 5.16 5.86 1.14 1.50 0.26+
MW2341 sbi IgG binding 46.74 40.99 0.88 15.80 0.39+
MW0084 spa Protein A 2347.95 143.31 0.06** 93.82 0.65+
MW0130 capG Capsule 0.18 2.25 12.75* 0.58 0.26++
MW2586 icaA Intercellular adhesin 0.14 0.21 1.55 0.13 0.60++
MW0516 sdrC Fibrinogen binding 0.22 0.18 0.79 0.05 0.29+++
MW0764 clfA Clumping factor 9.15 54.36 5.94* 19.21 0.35+++
MW2421 fnb Fibronectin biding 3.10 5.06 1.63** 8.27 1.63
MW1884 SCIN Complement inhibitor 9.86 53.69 5.45** 13.62 0.25+++
MW0088 sirA Iron acquisition 0.78 13.99 17.98* 0.17 0.01+
MW0094 sbnF Iron acquisition 0.05 8.23 167.55** 0.04 0.00++
MW1014 isdD Iron acquisition 0.32 14.91 46.98* 0.25 0.02+
a

GeneID in S. aureus strain MW2.

b

Expression ratio to gyrA (×100) at exponential phase.

c

Significant changes of expression of S. aureus grown in CDM(−) compared with TSB as determined by Student's t test; *, P < 0.05; **, P < 0.01; ***, P < 0.001.

d

Significant changes of expression of S. aureus grown in CDM(−) containing 3 μM FeCl3 compared with CDM(−) as determined by Student's t test; +, P < 0.05; ++, P < 0.01; +++, P < 0.001.