Table 3.
Antimicrobial spectra of leucocyclicin Q and lactocyclicin Q
| Indicator straina | MIC (μM)b |
|
|---|---|---|
| Leucocyclicin Q | Lactocyclicin Q | |
| Lactococcus lactis subsp. lactis JCM 7638 | 0.038 | 0.141 |
| L. lactis subsp. lactis ATCC 19435T | 0.038 | 0.141 |
| Lactococcus sp. QU 12 | 1.203 | 22.90 |
| Lactobacillus sakei subsp. sakei JCM 1157T | 0.038 | 0.015 |
| Weissella cibaria JCM 12495T | 2.405 | 0.710 |
| W. paramesenteroides JCM 9890T | 0.075 | ND |
| Pediococcus pentosaceus JCM 5885 | 2.405 | 0.550 |
| P. dextrinicus JCM 5887T | 0.038 | 0.141 |
| Enterococcus faecium JCM 5804T | 0.038 | 0.710 |
| E. faecalis JCM 5803T | 0.150 | 0.260 |
| Streptococcus salivarius JCM 5707T | 2.405 | 22.90 |
| S. bovis JCM 5802T | 0.601 | 22.90 |
| S. mutans JCM 5705T | 19.25 | NA |
| Bacillus coagulans JCM 2257T | 0.075 | 0.015 |
| B. subtilis subsp. subtilis JCM 1465T | 0.601 | 0.064 |
| B. cereus JCM 2152T | 2.405 | 11.40 |
| Kocuria rhizophila NBRC 12708 | 9.623 | 5.70 |
| Listeria innocua ATCC 33090T | 0.601 | 1.03 |
| Leuconostoc mesenteroides subsp. mesenteroides JCM 6124T | 0.300 | 1.03 |
| L. mesenteroides TK41401 | NA | 22.90 |
| Escherichia coli JM109 | 38.49 | 34.30 |
| E. coli NBRC 3301 | 38.49 | 17.30 |
| Staphylococcus aureus subsp. aureus ATCC 12600T | NA | 91.60 |
a
ATCC, American Type Culture Collection, Rockville, MD,; JCM, Japan Collection of Microorganisms, Saitama, Japan: NBRC, NITE Biological Resource Center, Chiba, Japan.
b
The antimicrobial spectrum of lactocyclicin Q was drawn from the previous report (36). Only the MIC against L. mesenteroides TK41401 was determined in this study. ND, not determined; NA, no activity even with maximum concentrations of leucocyclicin Q and lactocyclicin Q (38.49 and 91.60 μM, respectively).