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CD4 and CD8 T cells are not required for protective immunity at the time of i.n. challenge with Y. pestis CO92. (A) Experimental protocol. (B) Survival of i.n. iYp-plus-IL-12–vaccinated mice that were depleted of CD4 and/or CD8 T cells after vaccination but before i.n. infection with 103 CFU of Y. pestis CO92 (5 mice/group). **, P < 0.01, compared to the PBS group. These results represent a single experiment.
