Fig. 3.

Relative fitness coefficients of adaptive mutants isolated from fluconazole-exposed populations compared with the parental strain (different FP), DP-1 (A) and DP-2 (B), in the presence of 0.25 μg/ml of fluconazole (hatched bars) or without fluconazole (solid bars). The data shown are the averages and SD of a minimum of 3 biological replicates. The asterisks indicate that the relative fitness difference measured in the adaptive strains is statistically significant (P < 0.05, using an unpaired Student t test with unequal variance).