Fig. 11.

Transient transcriptional upregulation of agsB (A) and phosphorylation of MpkA (B) following exposure to micafungin in the wt and wsc disruptant strains. Strains were cultured at 30°C for 24 h, at which time micafungin was added to the medium and transcription of the agsB and histone H2B genes and the level of MpkA phosphorylation were monitored at 0, 30, 60, and 120 min. The y axis shows the level of mRNA relative to that of the histone H2B gene (A). *, statistically significant difference (P < 0.05) relative to the result obtained at 0 min.