Table 2.

Sensitivity, specificity, PPV, and NPV of different test algorithms for the detection of histologically confirmed CIN3+ or CIN2+ lesions

Test and lesion typea	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
HPV DNA
CIN3+	0.97 (0.92–1.00)	0.32 (0.25–0.40)	0.36 (0.28–0.43)	0.96 (0.91–1.00)
CIN2+	0.95 (0.91–1.00)	0.38 (0.30–0.47)	0.52 (0.44–0.60)	0.92 (0.85–1.00)
HPV DNA 8 gt
CIN3+	0.95 (0.89–1.00)	0.43 (0.35–0.51)	0.39 (0.31–0.47)	0.96 (0.91–1.00)
CIN2+	0.92 (0.86–0.98)	0.50 (0.41–0.58)	0.56 (0.48–0.64)	0.90 (0.82–0.97)
HPV DNA 5 gt
CIN3+	0.88 (0.80–0.96)	0.50 (0.42–0.58)	0.41 (0.32–0.49)	0.91 (0.85–0.98)
CIN2+	0.86 (0.79–0.93)	0.57 (0.48–0.66)	0.59 (0.50–0.67)	0.85 (0.78–0.93)
HPV mRNA
CIN3+	0.93 (0.87–1.00)	0.58 (0.50–0.66)	0.47 (0.38–0.56)	0.96 (0.91–1.00)
CIN2+	0.91 (0.85–0.97)	0.68 (0.60–0.77)	0.67 (0.58–0.75)	0.91 (0.86–0.97)
HPV mRNA 8 gt
CIN3+	0.90 (0.82–0.98)	0.64 (0.56–0.71)	0.49 (0.40–0.59)	0.94 (0.90–0.99)
CIN2+	0.87 (0.80–0.94)	0.74 (0.66–0.82)	0.70 (0.62–0.79)	0.89 (0.83–0.95)
HPV mRNA 5 gt
CIN3+	0.86 (0.78–0.95)	0.67 (0.59–0.74)	0.50 (0.41–0.60)	0.93 (0.88–0.98)
CIN2+	0.83 (0.75–0.91)	0.76 (0.69–0.84)	0.71 (0.62–0.80)	0.86 (0.80–0.93)
PreTect HPV Proofer
CIN3+	0.81 (0.71–0.91)	0.70 (0.63–0.77)	0.51 (0.41–0.62)	0.91 (0.85–0.96)
CIN2+	0.75 (0.66–0.84)	0.77 (0.70–0.85)	0.70 (0.61–0.79)	0.81 (0.74–0.88)

^a8 gt, eight HPV genotypes (HPV16, -18, -31, -33, -35, -45, -52, and -58); 5 gt, five HPV genotypes (HPV16, -18, -31, -33, and -45).