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. 2011 Nov;31(22):4609–4622. doi: 10.1128/MCB.05766-11

Fig. 4.

Fig. 4.

Expansion of luminal progenitor subsets in PyMT; Gata-3+/nlslacZ mammary lesions. (A) Representative FACS dot plot showing the expression of c-kit and CD14 in Lin− CD24+ cells of mammary adenomas (5 to 6 weeks) from PyMT; Gata-3+/+ and PyMT; Gata-3+/nlslacZ mice. (B) Histogram showing percentage of c-kit/CD14 cells in the CD24+ populations isolated from 5- to 6-week-old PyMT; Gata-3+/+ and PyMT; Gata-3+/nlslacZ mice (means ± standard errors of the mean [SEM] of results for five animals per group). (C) Histogram showing fold change (PyMT; Gata-3+/+ over PyMT; Gata-3+/nlslacZ) in tumor-initiating cell (TIC) capacity after transplantation of c-kit+, CD14+ c-kit−/lo, and CD14− c-kit− cells from PyMT; Gata-3+/+ and PyMT; Gata-3+/nlslacZ mice (means ± SEM of results from three independent experiments). *, P = 0.04. Student t test of fold change in TIC capacity for c-kit+ and CD14− c-kit− cells.