Table 4.
Summary of class I-restricted epitopes
| Animal | Epitopea | Patr restriction haplotype | Name of epitope | Sequence | Mutatedb | Escapedc |
|---|---|---|---|---|---|---|
| CH1530 | Predicted | A*0101 | E2617 | HYPCTINYTIFK | − | − |
| A*0101 | NS21011 | LLGPADGMVSK | − | − | ||
| A*0101 | NS4B1724 | MLAEQFKQK | − | − | ||
| B*2401 | NS5B2663 | CDLDPQARVAI | + | NT | ||
| Targeted | A*0701 | E1347 | MIAGAHWGVLd | − | − | |
| A*0701 | p7758 | SLAGTHGLVSFLf | + | + | ||
| A*0701 | p7789 | ALYGMWPLLLf | + | + | ||
| B*0802 | NS31524 | GCAWYELTPd | − | + | ||
| CH1564 | Predicted | B*1301 | Core41 | GPRLGVRAT | − | − |
| B*1301 | Core137 | IPLVGAPL | − | − | ||
| B*1301 | E2542 | TRPPLGNWF | − | − | ||
| B*0901 | NS31123 | CTCGSSDLY | − | − | ||
| B*1301 | NS31373 | IPFYGKAI | − | − | ||
| Targeted | A*0701 | E1347 | MIAGAHWGVLd | + | − | |
| B*0901 | E2462 | LTDFAQGWe | + | + | ||
| A*0701 | p7758 | SLAGTHGLVSFLf | + | + | ||
| A*0701 | p7789 | ALYGMWPLLLf | + | + | ||
| B*0901 | NS31565 | LTHIDAHFLd | − | − | ||
| A*0602 | NS31617 | TLHGPTPLLYe | + | + | ||
| A*0602 | NS4B2055 | MWSGTFPINAYf | + | + |
a
Predicted epitopes are epitopes described in other studies and restricted by a Patr allele expressed by the indicated chimpanzee; targeted epitopes are epitopes for which cognate CD8+ T cells were isolated from the indicated chimpanzee.
b
Amino acid change(s) occurred over time within minimal epitopes.
c
Amino acid change(s) within or outside epitopes impaired recognition by cognate CD8+ T cells. NT, not tested.
d
Epitopes for which specific CD8+ T cells were expanded only from the intrahepatic compartment.
e
Epitopes for which specific CD8+ T cells were expanded only from the peripheral blood.
f
Epitopes for which specific CD8+ T cells could be expanded from the peripheral blood and the intrahepatic compartment.