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2F5 UAs show broader specificity than does the mature 2F5 antibody. The effect of alanine substitution of each of the indicated residues of the 2F5 nominal epitope peptide on the binding of 2F5, UA variant 1, or UA variant 2 is plotted as a ratio of the binding of mutant to wild-type (WT) peptide. Critical residues showing >50% reduction in steady binding responses as measured by SPR analysis are circled.
