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Model for calpain-1-mediated Rad21 cleavage and sister chromatid separation. Cleavage of either one or both Rad21 molecules (represented by white incisions) in the cohesin handcuff by calpain-1 (CAPN1) can equally lead to a loss of sister chromatid cohesion and can also relieve cohesin-mediated catenation of sisters. Cohesin cleavage by calpain-1 may function as an additional mechanism to separate the sisters, aiding the Plk1-mediated prophase pathway.
