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Genotyping analysis of offspring from 15-1+/Flox 15-2+/− intercross of heterozygous mutant mice
| Time | No. of offspring |
No. of offspring with abnormalitya | ||
|---|---|---|---|---|
| WT (+/+ +/+) | 15-2 heterozygous (+/Flox +/−) | 15-2KO (Flox/Flox −/−) | ||
| E10.5 | 6 | 7 | 9 | 4 |
| E12.5 | 10 | 12 | 4 | 7 |
| E15.5 | 9 | 24 | 8 | 8 |
| E16.5 | 4 | 15 | 6 | 7 |
| E18.5 | 36 | 60 | 10 | 28 |
| P0 | ||||
| Alive | 10 | 29 | 2 | |
| Dead | 1 | 2 | 3 | |
| Weaningb | 153 | 290 | 0 | |
“Abnormality” indicates offspring whose genomic DNA could not be extracted.
Time of weaning, 1 to ∼5 weeks of age.
