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. 2011 Dec;85(23):12399–12409. doi: 10.1128/JVI.05707-11

Fig. 6.

Fig. 6.

(A) Number of transmitted or founder variants at 2 weeks postinfection in R, M, and S animals vaccinated with DNA/ALVAC/gp120 challenged with 6,100 or 470 TCID50 of SIVmac251 (left panel). In the right panel is depicted the number of transmitted or founder variants in R, M, and S animals challenged with 120 TCID50 of SIVmac251 and vaccinated with ALVAC/gp120 or gp120 only. The bars indicate the means ± the standard errors of the mean. (B) Number of SIVmac251 exposures to infection in R, M, and S animals challenged with 120 or 470 TCID50 of SIVmac251. The first group was vaccinated with DNA/ALVAC/gp120 and received up to two challenges of 470 TCID50 of SIVmac251. One M and two S animals were not infected after the two exposures, and they are marked with the symbol “x” and assigned to 3. The other animals were either vaccinated with ALVAC/gp120 or gp120 only and received weekly intrarectal challenges of 120 TCID50 of SIVmac251 until all of the animals became infected up to five exposures. Two M animals and one S animal from the group vaccinated with ALVAC/gp120 and one R animal from the group vaccinated with gp120 only were not infected after five exposures, and they are marked with the symbol “x” and assigned to 6.