Table 1.
Characterization of SPPV34, YMTV34, SPV032, and M029 protein function
| Characterization | Protein functiona |
|||||
|---|---|---|---|---|---|---|
| ΔE3L-Rev | ΔE3L | ΔE3L-SPPV34L | ΔE3L-YMTV34L | ΔE3L-SPV032L | ΔE3L-M029L | |
| Replication in HeLa cells | +++ | − | − | + | ++ | ++ |
| Inhibition of PKR | +++ | − | − | − | ++ | +++ |
| Inhibition of cytokine expression | +++ | − | + | + | ++ | +++ |
| Inhibition of antiviral effects of IFN-β | +++ | − | − | ++ | +++ | +++ |
| Pathogenicity in mice | +++ | − | − | − | − | − |
a
For comparative purposes, ΔE3L-Rev was denoted “+++”, while ΔE3L was denoted “−” for all of the functions analyzed, and each of the orthologues was compared with respect to ΔE3L-Rev and ΔE3L.