Fig. 1.

Genetic heterogeneity of HIV-1 Vpr from primary isolates. Vpr amino acid sequences from HIV-1 primary isolates of groups M (clades B, C, D, and H), N, O, and P were compared to that of the laboratory-adapted virus HxB (reference). There were two isolates each from clades B (B-13C and B-18E) and D (D-sh and D-lo). Residues identical to those of the reference sequence are indicated with dots, and deleted residues are indicated with dashes. The conservation of functionally important residues at positions 65 and 80 across Vprs from different HIV-1 groups was denoted.