Fig. 6.

Antiviral treatment partially reduces the increased frequency of anti-VACV memory CD8⁺ T cells. B6, IFN-γ^−/−, and Prf^−/− mice were infected with 10⁶ PFU VACV i.p., and 400 μg of cidofovir was administered i.p. at 2 dpi. At ≥30 dpi, individual spleens were collected, processed, and analyzed. (Top) Representative flow cytometry plots show the percentages of DimerX staining. (Bottom) Bar graph shows summary data for the percentages of DimerX staining for all the mice in the experiment. Data are means for five mice per group ± SEM and are representative of two independent experiments. **, P = 0.01.