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Antiretroviral properties of feline A3 proteins and their sensitivity to FIV Vif and mutants. 293T cells were cotransfected with 500 ng of pNL4-3ΔVif plus 10 ng of VR1012, VR-fA3Z3-HA, VR-fA3Z2-Z3-HA, or VR-fA3Z2a-HA and 40 ng of VR-FIV Vif-myc, FIV Vif mutant, or VR1012. The virus infectivity was assayed by infecting MAGI cells. Cells were fixed and stained for β-galactosidase activity. Virus infectivity in the absence of fA3s was set to 100%.
