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Schematic representation of multiple classes of the Cul5-EB-EC E3 complex. HIV/SIV Vif select Cul5 based on the presence of the HCCH motif (A), whereas cellular substrate receptors (VHL or SOCS3) utilize a Cul2/Cul5 box to interact with Cul2/Cul5 (B and C). FIV Vif uses a motif that is yet to be determined (D).
